科研情况 |
山东省医药生物技术学会青年工作委员会委员。主要从事于抗体药物研发以及功能性乳酸菌株筛选和免疫机制的研究。主持山东省自然科学基金青年基金项目1项，烟台市重点研发计划1项，参与多项省部级、国家重大科研项目，尤其是在优良乳酸菌株筛选平台的建设过程中进行了功能选育，并结合基因组学分析，表型鉴定以及免疫机制研究，围绕微生态与人体健康相关的热点和焦点问题，聚焦益生菌的粘附、拮抗和免疫功能，深入揭示特殊乳酸菌株发挥免疫功能的物质基础及其分子作用机制。以第一作者或通讯作者发表高水平科研论文10篇，申请发明专利8项，获得授权3项，制定各类标准5项。 代表性科研论文： [1] Chenpei Zhao; Huan Chen; Hao Liang; Xiaoyu Zhao; Wenli Tang; Maolian Wei; Youzhi Li; Jianlong Zhang; Xin Yu; Guozhong Chen; Hongwei Zhu; Linlin Jiang*; Xingxiao Zhang*; Lactobacillus plantarum RS-09 Induces M1-Type Macrophage Immunity Against Salmonella Typhimurium Challenge via the TLR2/NF-κB Signalling Pathway, Frontiers in Pharmacology, 2022, 13(832245) （IF= 5.988，SCI二区，通讯作者） [2] Xiaoyu Zhao, Chenpei Zhao, Leining Yang, Linlin Jiang*, Jianlong Zhang, Xin Yu, Guozhong Chen, Hongwei Zhu, Wenli Tang, Youzhi Li, Maolian Wei, Xingxiao Zhang*, Hong Jia*. Spatial and Temporal Persistence of Fluorescent Lactiplantibacillus plantarum RS-09 in Intestinal Tract. Front Microbiol. 2022 Mar 30;13:843650. （IF= 6.064，SCI二区，通讯作者） [3] Jiang Linlin#; Tang Jinxiu#; Bo Yongheng; Li Youzhi; Feng Tao; Zhu Hongwei; Yu Xin; Zhang Xingxiao*; Zhang Jianlong*; Wang Weiyi*; Cytotoxic Secondary Metabolites Isolated from the Marine Alga-Associated Fungus Penicillium chrysogenum LD-201810, Marine Drugs, 2020, 18(5): 276. （IF= 6.085，SCI二区，第一作者） [4] Linlin Jiang, Jianlong Zhang, Jinxiu Tang, Meng Li, Xiaoyu Zhao, Hongwei Zhu, Xin Yu, Youzhi Li, Tao Feng and Xingxiao Zhang*. Analyses of Aerosol Concentrations and Bacterial Community Structures for Closed Cage Broiler Houses at Different Broiler Growth Stages in Winter[J]. J Food Prot, 2018, 81(9): 1557-1564. （IF= 2.745，SCI三区，第一作者） [5] Linlin Jiang, Ming Yang*, Xiaoyun Zhang, Shiqi Bao, Li Ma, Dongmei Fan, Yuan Zhou, Dongsheng Xiong*, Yongsu Zhen*. A novel antibody-drug conjugate anti-CD19(Fab)-LDM in the treatment of B-cell non-Hodgkin lymphoma xenografts with enhanced anticancer activity. J Drug Target. 2016; 24(1):47-57. （IF= 5.016，SCI三区，第一作者） |
